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KMID : 0648620070120020069
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Korean Journal of Nosocomial Infection Control
2007 Volume.12 No. 2 p.69 ~ p.76
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The Emerging Strong Among Extended-Spectrum Β-Lactamase : CTM-M Enzymes
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Bae Il-Kwon
Lee Kyung-Won
Jeong Seok-Hoon
Song Won-Keun
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Abstract
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CTX-M-type extended-spectrum beta-lactamases (ESBLs) are the most wide spread enzymes among non-TEM and non-SHV plamid-mediated ESBLs, and have been found predominantly in Escherichia coli. CTX-M ESBLs have a wide substrate range, including penicillins and narrow- and expanded-spectrum cephalosporins, and as the designation "CTX" refers, these enzymes preferentially hydrolyze cefotaxime but not ceftazidime. At present, the CTX-M family comprises more than 60 enzymes that can be subclassified into 5 clusters by amino acid sequence similarities. In Korea, members of CTX-M-1 (CTX-M-3, CTX-M-12, CTX-M-15, and CTX-M-54) and CTX-M-9 (CTX-M-9 and CTX-M-14) clusters have been found. The rapid dissemination of CTX-M ESBLs involves strain or plasmid epidemics, but it also involves mobile elements including ISEcp1-like insertion sequences and ISCR1 element. A recent report shows that the blaCTX-M-14 gene from Korea is associated with not only ISEcp1-like insertion sequences but also ISCR1 element. ISCR1 element is a powerful genetic tool that can mobilize antibiotic resistance genes; therefore, further spread of the blaCTX-M-14 gene can be anticipated.
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KEYWORD
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Extended-Spectrum Β-Lactamase, CTX-M
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